2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Progesterone Receptor

Progesterone Receptor

NR3C3

Progesterone Receptor

Related Products

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Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0891R
    17α-Hydroxyprogesterone (Standard)
    		Agonist
    17α-Hydroxyprogesterone (Standard) is the analytical standard of 17α-Hydroxyprogesterone. This product is intended for research and analytical applications.
    17α-Hydroxyprogesterone (Standard)
  • HY-B1095S1
    Chlormadinone acetate-d6-1
    		Agonist ≥99.0%
    Chlormadinone acetate-d6-1 is deuterium labeled Chlormadinone acetate.
    Chlormadinone acetate-d<sub>6</sub>-1
  • HY-B1089
    Ethynodiol diacetate
    		Agonist 99.85%
    Ethynodiol diacetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ethynodiol diacetate
  • HY-B0652
    Etonogestrel
    		Agonist 99.14%
    Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs. Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs).
    Etonogestrel
  • HY-131547
    Org OD 02-0
    		Agonist 99.7%
    Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary.
    Org OD 02-0
  • HY-B0554S
    Norethindrone-d6
    		Agonist 98.60%
    Norethindrone-d6 is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Norethindrone-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norethindrone-d<sub>6</sub>
  • HY-B0469S
    Medroxyprogesterone acetate-d3
    		Agonist 98.13%
    Medroxyprogesterone acetate-d3 is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1].
    Medroxyprogesterone acetate-d<sub>3</sub>
  • HY-14959
    Ulipristal
    		Modulator ≥98.0%
    Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system.
    Ulipristal
  • HY-B0554R
    Norethindrone (Standard)
    		Agonist 99.01%
    Norethindrone (Standard) is the analytical standard of Norethindrone. This product is intended for research and analytical applications. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.
    Norethindrone (Standard)
  • HY-N0437S2
    Progesterone-13C3
    		Agonist 99.60%
    Progesterone-13C3 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
    Progesterone-<sup>13</sup>C<sub>3</sub>
  • HY-12738
    PF-3882845
    		Antagonist 99.90%
    PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy. PF-3882845 also binds to progesterone receptor (PR) with the binding IC50 of 310 nM.
    PF-3882845
  • HY-B0742R
    Hydroxyprogesterone caproate (Standard)
    Hydroxyprogesterone caproate (Standard) is the analytical standard of Hydroxyprogesterone caproate. This product is intended for research and analytical applications.
    Hydroxyprogesterone caproate (Standard)
  • HY-B0257R
    Levonorgestrel (Standard)
    		Agonist
    Levonorgestrel (Standard) is the analytical standard of Levonorgestrel. This product is intended for research and analytical applications.
    Levonorgestrel (Standard)
  • HY-B0648S
    Medroxyprogesterone-d3
    		Agonist
    Medroxyprogesterone-d3 is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
    Medroxyprogesterone-d<sub>3</sub>
  • HY-N0437S3
    Progesterone-13C2
    		Agonist 99.7%
    Progesterone-13C2 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
    Progesterone-<sup>13</sup>C<sub>2</sub>
  • HY-B0257S1
    Norgestrel-d6
    		Agonist 99.53%
    Norgestrel-d6 is the deuterium labeled Levonorgestrel. Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives. Norgestrel-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norgestrel-d<sub>6</sub>
  • HY-16775
    Vilaprisan
    		Modulator 99.75%
    Vilaprisan is a selective progesterone receptor modulator (SPRM), which targets progesterone receptors. Vilaprisan can inhibit cell proliferation and stimulate apoptosis. Vilaprisan has oral efficacy and anti-proliferative activity against uterine leiomyoma (UF).
    Vilaprisan
  • HY-B0111S
    Drospirenone-d4
    		Agonist
    Drospirenone-d4 is the deuterium labeled Drospirenone. Drospirenone (Dihydrospirorenone) is a synthetic progestin that is an analog to spironolactone[1][2].
    Drospirenone-d<sub>4</sub>
  • HY-13676S
    Megestrol acetate-d3
    		Inhibitor
    Megestrol acetate-d3 is the deuterium labeled Megestrol acetate. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway[1][2][3][4][5].
    Megestrol acetate-d<sub>3</sub>
  • HY-13683S1
    Mifepristone-13C,d3
    		Antagonist
    Mifepristone-13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Mifepristone-<sup>13</sup>C,d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity